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Sample Practice Questions

Question 1 FULLY WORKED EXAMPLE

A 24-year-old woman is brought to the emergency department by her partner. She has had 5 days of decreased need for sleep, rapid pressured speech, and grandiose claims that she has been chosen to lead a global movement. She reports hearing voices commenting on her actions. She has no prior psychiatric history and no substance use. Vital signs: BP 118/74 mmHg, HR 92/min, temperature 37.1?C. Laboratory: TSH 1.8 mIU/L (0.4-4.0), urine toxicology negative, urine pregnancy test positive. Which is the most appropriate next step in management?

A) Start lithium carbonate and arrange outpatient follow-up in 1 week
B) Start olanzapine and arrange inpatient psychiatric admission ✓ Correct
C) Start sodium valproate and arrange outpatient follow-up in 1 week
D) Start carbamazepine and arrange outpatient follow-up in 1 week
Explanation:
The deciding finding is the positive urine pregnancy test in a patient with first-episode mania with psychotic features. Olanzapine is an atypical antipsychotic with the best-established evidence for acute mania and is relatively safe in pregnancy compared with valproate and carbamazepine, and inpatient admission is indicated because of psychosis, lack of insight, and risk. Lithium is also teratogenic (Ebstein anomaly) and requires monitoring that is difficult to initiate safely in an acute emergency. Sodium valproate is highly teratogenic and contraindicated in pregnancy. Carbamazepine is also teratogenic and not first-line for acute mania. NICE guidance on antenatal and postnatal mental health supports avoiding valproate and using antipsychotics with the lowest risk profile in pregnancy.
References: NICE guideline NG192, Antenatal and postnatal mental health: clinical management and service guidance
Question 2 TRY IT — TAP AN ANSWER

A 68-year-old man with a 3-year history of Parkinson's disease on levodopa/carbidopa is admitted with 2 weeks of visual hallucinations of small animals, fluctuating attention, and daytime somnolence. He has no fever and no focal neurological deficit. Vital signs: BP 132/80 mmHg, HR 78/min, temperature 36.8?C. Laboratory: WBC 7.2 x109/L, CRP 4 mg/L, creatinine 1.0 mg/dL. Which is the most appropriate next step in management?

A) Start quetiapine and reduce the levodopa dose
B) Start haloperidol and continue the levodopa dose
C) Start risperidone and continue the levodopa dose
D) Start olanzapine and continue the levodopa dose
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Question 3 TRY IT — TAP AN ANSWER

A 32-year-old woman with a 6-month history of major depressive disorder is started on sertraline 50 mg daily. Two weeks later she presents with confusion, agitation, diaphoresis, and tremor. She reports she also took linezolid for a skin infection started 3 days ago. Vital signs: BP 158/96 mmHg, HR 118/min, temperature 38.6?C. Laboratory: creatine kinase 1,850 U/L (30-200), WBC 11.5 x109/L. Which is the most likely diagnosis?

A) Neuroleptic malignant syndrome
B) Serotonin syndrome
C) Malignant hyperthermia
D) Anticholinergic toxicity
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Question 4 TRY IT — TAP AN ANSWER

A 45-year-old man with schizophrenia on clozapine 300 mg daily for 8 weeks presents with 2 days of fever, sore throat, and malaise. Vital signs: BP 110/70 mmHg, HR 104/min, temperature 38.4?C. Laboratory: WBC 2.1 x109/L, absolute neutrophil count 0.9 x109/L, CRP 28 mg/L. Which is the most appropriate next step in management?

A) Continue clozapine and repeat the full blood count in 1 week
B) Reduce clozapine to 150 mg daily and repeat the full blood count in 3 days
C) Stop clozapine immediately and arrange urgent medical admission
D) Add lithium to stimulate neutrophil production and continue clozapine
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Question 5 TRY IT — TAP AN ANSWER

A 29-year-old woman with bipolar I disorder on lithium carbonate for 2 years presents with 3 days of coarse tremor, vomiting, and unsteady gait. She recently started ibuprofen for back pain. Vital signs: BP 108/68 mmHg, HR 88/min, temperature 37.0?C. Laboratory: lithium level 2.4 mmol/L (0.6-1.2), creatinine 1.6 mg/dL (baseline 0.9), sodium 138 mmol/L, TSH 2.0 mIU/L. Which is the most appropriate next step in management?

A) Continue lithium at the same dose and stop ibuprofen
B) Stop lithium, give intravenous fluids, and arrange hemodialysis if levels remain elevated
C) Reduce lithium dose by half and repeat the level in 24 hours
D) Start sodium bicarbonate to enhance lithium excretion and continue lithium
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Specialist Psychiatry (PSY5961) Questions for DHA Speciality — FAQ

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