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Master Specialist Gastroenterology (GES5171)
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Sample Practice Questions

Question 1 FULLY WORKED EXAMPLE

A 58-year-old man with a 3-day history of severe epigastric pain radiating to the back, vomiting, and no alcohol use is admitted. He takes ramipril for hypertension and atorvastatin. Examination: BP 118/74 mmHg, HR 104/min, temperature 37.8°C, BMI 34 kg/m². Serum amylase 980 U/L (reference

A) Urgent endoscopic retrograde cholangiopancreatography
B) CT of the pancreas with contrast ✓ Correct
C) Start prophylactic broad-spectrum antibiotics
D) Immediate laparoscopic cholecystectomy
Explanation:
The deciding finding is the absence of gallstones on ultrasound combined with normal ALT and bilirubin, which makes a biliary cause unlikely and shifts the working diagnosis toward non-biliary acute pancreatitis, most likely hypertriglyceridaemia or idiopathic. In a patient failing to improve at 48 hours, a contrast-enhanced CT of the pancreas is the standard next investigation to assess for pancreatic necrosis and local complications, as recommended by the International Association of Pancreatology guidelines on acute pancreatitis. ERCP is inappropriate because there is no evidence of biliary obstruction or cholangitis. Prophylactic antibiotics are not indicated in sterile necrotising pancreatitis and are reserved for proven infection. Cholecystectomy is not indicated in the absence of gallstones and would not address the current deterioration.
References: International Association of Pancreatology/APA Evidence-Based Guidelines for the Management of Acute Pancreatitis (Working Group on Acute Pancreatitis).
Question 2 TRY IT — TAP AN ANSWER

A 34-year-old woman presents with a 6-month history of intermittent bloody diarrhoea, urgency, and tenesmus. She has no recent antibiotic use or travel. Examination: HR 88/min, BP 112/70 mmHg, temperature 36.9°C, weight stable. Haemoglobin 108 g/L, CRP 18 mg/L, albumin 38 g/L. Stool culture and Clostridioides difficile toxin are negative. Flexible sigmoidoscopy shows continuous erythema and loss of vascular pattern from the rectum to the sigmoid colon with contact bleeding. What is the most appropriate initial treatment?

A) Oral prednisolone
B) Oral mesalazine
C) Oral azathioprine
D) Intravenous infliximab
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Question 3 TRY IT — TAP AN ANSWER

A 58-year-old man with Child-Pugh B cirrhosis and a prior variceal bleed 8 months ago presents with melena and a haemoglobin of 78 g/L. He is haemodynamically stable after resuscitation. He is on propranolol 40 mg twice daily for variceal prophylaxis. Upper endoscopy shows large oesophageal varices with stigmata of recent haemorrhage but no active spurting. Which is the most appropriate immediate management?

A) Continue propranolol and arrange repeat endoscopy in 24 hours
B) Start intravenous terlipressin and intravenous ceftriaxone, then band ligation at the same endoscopy session
C) Start intravenous octreotide alone and defer band ligation until bleeding has fully stopped for 48 hours
D) Stop propranolol, transfuse to a haemoglobin target of 100 g/L, and start oral carvedilol
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Question 4 TRY IT — TAP AN ANSWER

A 34-year-old woman at 26 weeks' gestation presents with a 3-day history of bloody diarrhoea, urgency, and a CRP of 68 mg/L. She has a known diagnosis of ulcerative colitis maintained on mesalazine. Flexible sigmoidoscopy confirms moderate active distal colitis. She has no signs of sepsis and fetal monitoring is normal. Which is the most appropriate treatment for her flare?

A) Oral prednisolone 40 mg daily
B) Oral azathioprine
C) Oral methotrexate
D) Oral ciprofloxacin and metronidazole
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Question 5 TRY IT — TAP AN ANSWER

A 62-year-old man with atrial fibrillation on warfarin (INR 2.4) presents with an acute upper GI bleed from a duodenal ulcer with a visible vessel, which is successfully treated with dual endoscopic therapy. He is haemodynamically stable. His HAS-BLED score is 3 and CHA2DS2-VASc is 4. Which is the most appropriate management of his anticoagulation?

A) Continue warfarin at the same dose without interruption
B) Stop warfarin and start low-dose aspirin
C) Withhold warfarin and restart once haemostasis is secure, bridging with heparin only if there is a very high thrombotic risk
D) Reverse warfarin with intravenous vitamin K and restart warfarin after 4 weeks
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Specialist Gastroenterology (GES5171) Questions for DHA Speciality — FAQ

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