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Master Obstetrics & Gynecology
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HIGH YIELD NOTES ~5 min read

Core Concepts

Obstetrics & Gynecology encompasses female reproductive health across the lifespan, from adolescence through menopause and beyond. Key areas include antenatal, intrapartum, and postpartum care, management of high-risk pregnancies, reproductive endocrinology, contraception, infertility, gynecological oncology, pelvic floor disorders, and preventative health screenings. Emphasize patient safety, evidence-based practice, and cultural sensitivity, particularly within the UAE context which often presents with high rates of gestational diabetes and vitamin D deficiency. Early detection and management of complications are paramount to maternal and fetal well-being.

Clinical Presentation

  • **Obstetrics:**
    • **Early Pregnancy:** Amenorrhea, nausea/vomiting, breast tenderness. Vaginal bleeding and/or abdominal pain (miscarriage, ectopic pregnancy). Hyperemesis gravidarum.
    • **Late Pregnancy:** Reduced fetal movements. Vaginal bleeding (placenta previa, placental abruption, cervical changes). Abdominal pain (preterm labor, abruption). Headache, visual changes, epigastric pain (pre-eclampsia). Leakage of fluid (PPROM).
    • **Postpartum:** Perineal pain, lochia changes, fever (endometritis), breast engorgement/pain (mastitis), postpartum hemorrhage (PPH).
  • **Gynecology:**
    • **Menstrual Disorders:** Abnormal Uterine Bleeding (AUB - menorrhagia, metrorrhagia, post-coital, post-menopausal bleeding), dysmenorrhea, amenorrhea, oligomenorrhea.
    • **Pelvic Pain:** Acute (ruptured ovarian cyst, PID, ectopic), chronic (endometriosis, adenomyosis, adhesions). Dyspareunia.
    • **Vaginal Symptoms:** Discharge, itching, odor (vaginitis, STIs). Vaginal dryness, atrophy.
    • **Pelvic Masses:** Abdominal distension, pressure symptoms, palpable mass (fibroids, ovarian cysts/tumors, uterine prolapse).
    • **Infertility:** Inability to conceive after 12 months (or 6 months if >35 years).
    • **Urinary Symptoms:** Stress, urge, or mixed incontinence. Recurrent UTIs.
    • **Breast Symptoms:** Lumps, pain, nipple discharge, skin changes.

Diagnosis (Gold Standard)

**Obstetrics:** Pregnancy confirmed by urine/serum hCG, then transvaginal ultrasound (TVUS) for viability, dating, and exclusion of ectopic pregnancy. Gestational Diabetes Mellitus (GDM): Oral Glucose Tolerance Test (OGTT) at 24-28 weeks. Pre-eclampsia: New onset hypertension (≥140/90 mmHg) with proteinuria and/or end-organ dysfunction. Ectopic pregnancy: Positive hCG with empty uterus on TVUS, often with adnexal mass/fluid. Placenta previa: TVUS. PPH: Clinical estimation of blood loss (>500mL vaginal, >1000mL C-section).
**Gynecology:** AUB: TVUS for structural causes, endometrial biopsy/hysteroscopy for endometrial pathology (especially post-menopausal bleeding). Pelvic Inflammatory Disease (PID): Clinical diagnosis (pelvic pain, cervical motion tenderness, adnexal tenderness), often supported by elevated inflammatory markers. Ovarian cysts/masses: TVUS, sometimes MRI. Cervical cancer screening: Pap smear (cytology), HPV testing; diagnosis by colposcopy with directed biopsy. Endometrial cancer: Endometrial biopsy. Breast lump: Triple assessment (clinical exam, imaging (mammogram/ultrasound), biopsy). STIs: Nucleic Acid Amplification Tests (NAATs).

Management (First Line)

**Obstetrics:** Antenatal care: Folic acid, iron, vitamin D supplementation, routine screenings. GDM: Diet, exercise, then metformin or insulin. Pre-eclampsia: Delivery is definitive cure, magnesium sulfate for seizure prophylaxis, antihypertensives for BP control. Ectopic pregnancy: Methotrexate (stable, small, unruptured) or laparoscopic salpingectomy. PPH: Uterine massage, oxytocin, other uterotonics (carboprost, misoprostol), surgical exploration if refractory. Preterm labor: Tocolytics (short-term), corticosteroids (fetal lung maturity), magnesium sulfate (neuroprotection <32w). Rh incompatibility: Anti-D immunoglobulin.
**Gynecology:** AUB: Hormonal contraceptives (COCs, LNG-IUS), NSAIDs, tranexamic acid; endometrial ablation or hysterectomy for refractory cases. PID: Broad-spectrum antibiotics (e.g., ceftriaxone + doxycycline + metronidazole). Endometriosis: NSAIDs, hormonal suppression (COCs, GnRH agonists), laparoscopic surgery. Fibroids: Symptomatic management, GnRH agonists, uterine artery embolization, myomectomy, hysterectomy. Cervical cancer: Depends on stage, ranging from LEEP/conization to hysterectomy, radiation, chemotherapy. HPV vaccination for prevention. PCOS: Lifestyle modification, COCs (menstrual regulation, hirsutism), metformin (insulin resistance), clomiphene/letrozole (fertility). Contraception: Wide range including COCs, progestin-only pills, IUDs, implants, barrier methods.

Exam Red Flags

  • **Obstetrics:**
    • Sudden, severe abdominal pain with vaginal bleeding in late pregnancy: Placental abruption or uterine rupture.
    • Reduced fetal movements: Fetal compromise, requires urgent assessment.
    • Sudden, severe headache, visual changes, epigastric pain in late pregnancy: Severe pre-eclampsia or HELLP syndrome.
    • Shoulder dystocia, cord prolapse, uterine inversion, amniotic fluid embolism: OBGYN emergencies requiring immediate action.
    • Unexplained hypotension, tachycardia, or oliguria in postpartum period: Postpartum hemorrhage until proven otherwise.
  • **Gynecology:**
    • Post-menopausal bleeding: Endometrial cancer until proven otherwise; requires urgent endometrial biopsy.
    • Acute, severe unilateral pelvic pain with signs of hypovolemic shock: Ruptured ectopic pregnancy or ovarian torsion.
    • Persistent/recurrent pelvic mass in a post-menopausal woman, especially with ascites, weight loss, or early satiety: Ovarian malignancy.
    • Any new, suspicious breast lump, particularly with skin changes, nipple retraction, or discharge: Requires urgent triple assessment.
    • Unexplained severe systemic illness with gynecological source: Septic shock from PID or tubo-ovarian abscess.

Sample Practice Questions

Question 1

A 24-year-old nulligravida presents with a 2-year history of irregular periods (oligomenorrhea), increasing facial hair, and difficulty losing weight. Her BMI is 32 kg/m². Laboratory tests reveal elevated total testosterone and a high LH/FSH ratio. A transvaginal ultrasound shows bilaterally enlarged ovaries with multiple small follicles arranged peripherally. She is not currently seeking pregnancy. Which of the following is the most appropriate initial management strategy for this patient's anovulation and hirsutism?

A) Combined oral contraceptive pills (COCPs) and lifestyle modification.
B) Clomiphene citrate.
C) Spironolactone alone.
D) Gonadotropin injections.
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Question 2

A 62-year-old woman, postmenopausal for 10 years, presents with a 2-week history of intermittent vaginal bleeding. She has no other complaints and is not on hormone replacement therapy. Her physical examination is unremarkable. What is the most appropriate initial investigation to determine the cause of her bleeding?

A) Serum FSH and LH levels.
B) Transvaginal ultrasound (TVUS).
C) Diagnostic hysteroscopy.
D) Endometrial biopsy (pipelle biopsy).
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Question 3

A 32-year-old G2P1 woman is in active labor at 39 weeks gestation. Her membranes ruptured 4 hours ago. Fetal cardiotocography (CTG) shows recurrent late decelerations, with minimal variability. She is 7 cm dilated, 90% effaced, and the fetal head is at -1 station. What is the most appropriate immediate action?

A) Administer intravenous fluids and change maternal position
B) Prepare for immediate vacuum-assisted delivery
C) Administer tocolytics to stop contractions
D) Prepare for immediate Cesarean section
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